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NAD levels decline significantly with age, affecting metabolism and cellular function

In sickle cell anemia oxidative stress can trigger eryptosis and the release of red blood cell microparticles (RBC-MPs), which are small phospholipid-containing vesicles implicated in physiological processes such as hemostasis and potentially linked to macrovascular dysfunction

The choice of different time points in this study was based on literature reports indicating significant increases in periapical lesion volume between 14 and 21 days, followed by stability until 28 days of pulp exposure (Minhoto et al., 2021)