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Moreover, a recent randomized crossover study in healthy women demonstrated that prolonged mild sleep restriction markedly increased endothelial oxidative stress without activating compensatory antioxidant responses, due to reduced expression of DCUN1D3 gene, a regulator of the Nrf2-mediated antioxidant pathway, thereby suggesting a mechanistic link between insufficient sleep and vascular oxidative injury 78

Nanoparticle-cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy

doi: 10.1158/0008-5472.CAN-16-1404 41 AyariCBesanconMBergeronALaRueHBussieresVFradetY

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