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Valproate should not be used to treat women with epilepsy or bipolar disorder who are pregnant or who plan to become pregnant unless other medications have failed to provide adequate symptom control or are otherwise unacceptable

These results suggested that responsive CRPCs exhibit a distinct AR cistrome and differential biological role of the AR compared to CRPCs with innate resistance that could be exploited for the development of a predictive biomarker [65]

Urinary concentrations of the -oxidation metabolites of VPA were low, whereas concentrations of -oxidation metabolites were high