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Summary Selenium is a powerful antioxidant that fights oxidative stress and helps defend your body from chronic conditions, such as heart disease and cancer

The double KO (DKO) mice also exhibit robust lysosomal and FTLD- GRN -like pathologies including neurodegeneration and TDP-43 inclusions in the brainstem and spinal cord [92, 93, 193]

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Overall, these findings provide substantial evidence for the role of ROS in inducing apoptotic cell death, establishing that ROS are as a promising pathway in tumor therapy