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Takashi Tsuchiya (Department of Surgery, Sendai City Medical Center, Miyagi, Japan) for their cooperation in each collaboration and their critical comments and discussion during the preparation of this manuscript

Deletion of Cth reduces gastritis in acute models of H

In the mitochondrial matrix, SOD2 together with Prx3, GPx, the GSH/GSSG couple and the Trx2/TrxR2 system confines H 2 O 2 and supports controlled redox relays to metabolic enzymes and DNA repair machineries, whereas in the intermembrane space (IMS), SOD1, cytochrome c redox cycling and p66^Shc shape signals that can reach the cytosol

Although the exact processes by which it achieves these effects are still being investigated, the compounds capacity to control cellular metabolism presents a viable path for optimizing health