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These pathogenic processes ultimately result in massive -cell loss and absolute insulin deficiency, thereby inducing dysregulation of glucose homeostasis (164)

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Males mainly restore fecal butyrate levels and inhibit the expression of TNF- in the ascending colonic mucosa, whereas females focus on repairing intestinal epithelial tight-junction proteins (TJPs) and inhibiting myeloperoxidase (MPO) activity

A scientific review of MSC research notes that early studies suggest treatment can be feasible and generally well tolerated