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A key protein in axonal transport is Stathmin 2 (STMN2), which aids in axonal regrowth after injury and is found to be altered specifically by the toxic accumulations of TDP-43 and is found in lower quantities in spinal cords of mouse models of ALS [202, 287]

Nevertheless, further validation in larger clinical cohorts is required before such an approach can be broadly implemented

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Chronic inflammation Chronic inflammation is a slow process that operates in silence, with clinical consequences only apparent at later stages when the damage and resulting clinical sequelae are often irreversible (42)