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Using the mean and standard deviation of each log-normal distribution, random samples of size n = 10000 were produced for each kinetic parameter of interest: When studying the glutathione system, simulations were run 10000 times (iterating through the random sample of kinetic values collected)

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To survive, tumors employ multiple strategies, including upregulation of antioxidant systems (e.g., elevated GSH levels), increased production of signaling molecules such as nitric oxide (NO), and secretion of pro-angiogenic growth factors like vascular endothelial growth factor (VEGF), fibroblast growth factors (FGFs), and transforming growth factor (TGF) to stimulate blood vessel formation

Taylor RA et al