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doi: 10.1016/j.ijbiomac.2023.126013

329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes

DEG treatment decreased 5hmC and increased H3K4me3, similarly to ML226 treatment, but had no effect on HIF-1 stabilization (Fig

However, specific data on burning sensations as a distinct symptom are not separately quantified in the prescribing information