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10.1249/MSS.0000000000000683 167

Acne was used as a disease model in order to look at the molecular response of the skin microbiota to host metabolite signalling in disease pathogenesis

Research goals: Metabolic & Weight Description Retatrutide (development code LY3437943) is a synthetic, once-weekly triple agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptors that has been the subject of peer-reviewed phase 1 and phase 2 randomized controlled trials published in The New England Journal of Medicine , The Lancet , and Nature Medicine , including investigations of body weight, glycemic control, and hepatic steatosis in adult human participants

Second, the launch of phase I human clinical studies by academic centers or non-commercial consortia, driven by scientific interest rather than patent considerations