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(5, 6, 7) Ibuprofen and other NSAIDs inhibit cyclooxygenase, an enzyme that produces inflammatory mediators, called prostanoids, from arachidonic acid

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Moreover, eltrombopag, a thrombopoietin receptor agonist approved for the treatment of idiopathic thrombocytopenic purpura and aplastic anemia, has also shown to be an efficient iron chelator, mobilizing iron and reducing ROS working synergistically with other iron chelators in vitro (160)