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In summary, MND-ART-GEL effectively triggered ICD and downregulated STAT3, thereby remodeling the immunosuppressive microenvironment of TNBC and eliciting a robust antitumor immune response in vivo

The SAM concentration is influenced by the folate cycle and the rest of one-carbon metabolism via the methionine synthase(MS) reaction that remethylates homocysteine to methionine

The findings obtained suggested that the SDS factor structure is the same across gender with equally robust associations between the underlying constructs and the observed indicators across genders, thus providing additional support for the four-factor structure of the SDS