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doi:10.1016/j.josat.2023.209086 50

alcohol-related thiamine deficiency leads to acute neurological condition (Wernicke's encephalopathy) with a possibly fatal outcome, and chronic neurological condition (Korsakoff's syndrome), an impairment memory disorder

NHS England has been blunt on the point

Specifically, as Figure 4 shows, the de novo biosynthesis of guanosine ribonucleotides demonstrated an 11.38% mediation effect on LC outcomes, mediated through Fructosyllysine