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Eur J Cardiovasc Prev Rehabil

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found that targeting cGAS and inhibiting lactylation modifications can promote the transition of microglia from the M1 phenotype to a repair phenotype [110], the addition of lactate has no effect on the expression of A2 astrocytes and only weakens M1 polarization process [57]

The only available selective beta-blocker medication is betaxolol (Betoptic, Betoptic S)