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Description

A prevalent form of chemoresistance observed in numerous cancers is multidrug resistance (MDR) that is frequently mediated by P-glycoprotein (MDR1) and MDR-related proteins (MRP1 and MRP2) via ATP-dependent efflux [100]

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Another report revealed that a G1m1 allotype in the IgG1 created a protease cleavage site in the CH3 domain of the antibody Fc and enabled presentation of a CH3 1529 peptide epitope (78)