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Sao Paulo Medical Journal = Revista Paulista de Medicina

[67] demonstrated that sevoflurane can reduce neuronal apoptosis by mediating the E2F transcription factor 1/enhancer of zeste homolog 2/tissue inhibitor of metalloproteinases 2 (E2F1/EZH2/TIMP2) regulation axis, thereby protecting rats from brain I/R injury

[DOI] [PubMed] [Google Scholar] [26].Hayward MG, Keatinge WR

it can happen because of many reasons including direct exposure to UV radiation on exposed areas of skin, immunogenic skin problems, DNA damage due to various reasons, skin color, sun tanning bed, and many more