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It spreads through the bite of infected black-legged ticks, sometimes called deer ticks

5.3 Human evidence of transgenerational effects Although human data documenting transgenerational EED effects remain limited due to the extended timeframes required for multigenerational studies, emerging evidence provides preliminary support for intergenerational inheritance of reproductive impairments

These components can activate the Nrf2 antioxidant pathway, upregulate the expression of antioxidant enzymes such as SOD and GSH-Px, and protect the activity of the CYP450 metabolic enzyme system

Analysis of single-cell RNA sequencing Single-cell RNA sequencing (scRNA-seq) data (HRA000425) were downloaded from Genome Sequence Archive (SRA)-Human databases in China National Center for Bioinformation 16 , converted into FASTQ format using fasterq-dump software (sratoolkit 3.0.2, NCBI, NIH, Bethesda, MD, USA), converted into a matrix data file using Cell Ranger software version 3.0.2 (10xGenomics, Pleasanton, CA, USA), converted into Seurat objects using Seurat 5.0.1 software (Satija lab, Lower Manhattan, New York, NY, USA), and plotted for t -distributed stochastic neighbor embedding ( t -SNE) visualization