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License Transfer: Changing the sponsor of therapeutic goods The sponsor of therapeutic goods here refers to the person or company in relation to whom goods are registered, listed, or included in an entry in the Australian Register of Therapeutic Goods (ARTG)

Section 1886(d)(13)(B) of the Act requires the Secretary to use data the Secretary determines to be appropriate to establish the qualifying counties

However, the proteins identified as differentially expressed between non-splenectomized -thalassemia/HbE patients and healthy volunteers included a number of cytoskeletal proteins (F-actin -capping protein subunit beta, myosin light polypeptide 6, myosin regulatory light chain 12A, myosin-9, Rho GDP-dissociation inhibitor 2, transgelin-2, PDZ and LIM domain protein 1, and tropomyosin alpha-4 chain) as well as heat shock protein 70 kDa protein, integrin alpha IIb, beta-2-microglobulin, hemoglobin subunit beta, platelet factor 4 (or chemokine (C-X-C motif) and leukocyte elastase inhibitor

It has been shown to induce apoptosis by activating pro-apoptotic proteins (e.g., Bax, p53) and inhibiting antiapoptotic factors (e.g., Bcl-2) (38)