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The two compounds act on different systems pharmacologically

They found that participants who took collagen experienced a greater increase in patellar tendon cross-sectional area (+6.8 mm) than the placebo group (+1.2 mm)

Zp and Rp are heavily methylated and silenced in latent infection, whereas histone acetylation of Zp and Rp enhances gene accessibility and promotes the binding of transcription factors during lytic replication (Speck et al., 1997