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These data, taken together, suggest that the NF-B pathway is activated in SGNs after peroxynitrite treatment and GPX1 can partially block the nuclear translocation of NF-B/p65 and inhibit the activation of the NF-B signaling

Allow me to summarize the authors line of reasoning: Red meat must cause heart disease somehow, because epidemiological studies (which have no power to demonstrate cause and effect) suggest that people who eat more red meat are at higher risk for heart disease

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