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PRDM6 acts as a transcription suppressor by interacting with class I HDACs and EHMT2 to induce cell proliferation and inhibit cell differentiation

As a matter of fact, this protective effect is achieved through the regulation of GSH metabolic pathways, prevention of DNA damage, control of cell proliferation and survival, as well as inhibition of angiogenesis and metastasis [84,85]

Among these, T4 does not possess hormonal activity, while T3 has very high hormonal activity and is the principal hormone exerting the effects of thyroid hormones