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While clinically useful, this classification has been increasingly questioned due to its reliance on arbitrary time cutoffs and its inability to reflect the underlying biological diversity of resistance mechanisms [11,12,13]

[213] Wang J, Liu Z

In clinical trials, participants on the highest dose lost nearly 30% of their body weight in 68 weeks, substantially more than either semaglutide or tirzepatide achieved

The migratory abilities of these cells, and their propensity to seed different neural niches, can give rise to the genomic heterogeneity as seen in BM patients [70]