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Such histone modifications have now been identified within the FXN gene in FRDA cells, tissues, and mouse models, predominantly at the region immediately upstream of the expanded GAA repeats, indicating that the FXN gene is subject to heterochromatin silencing (Sandi et al., 2013) (Table 1, Figure 1)

However, their relative abundance during growth on all substrates diminished relative to DCMF, suggesting that it is unlikely they are primary consumers of these substrates