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Free heme has also been shown to promote inflammatory gene transcription in macrophages via TLR4 and NLRP3 inflammasome signaling, which have both been implicated in worsened atherosclerosis 72,73,74,75 (Fig

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7A, the intensity of new CENP-A (SNAP-CENP-A) was significantly reduced in the G1 phase of KNL2 Off cells expressing HJURP WT (cKO-KNL2 cells in the presence of IAA) or KNL2 On cells expressing HJURP 2E (cKO-KNL2 cells in the absence of IAA)