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The headline mechanisms: Angiogenesis via VEGFR2/Akt/eNOS: This is clinically significant because tendons and ligaments are notoriously hypovascular

Blood samples were collected 1 h after each second injection (at 12, 24, and 48 h), and serum uric acid concentrations were analyzed to assess treatment efficacy and monitor hyperuricemia progression

Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status

However, as an emerging discipline, the preparation and characterization, targeted delivery, and controlled release of nanomaterials remain a challenge, and the issues of biosafety, efficacy complexity, cost, and regulation also need to be optimized