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The substrate-binding domain has a three-layer alpha/beta/alpha structure

Nonetheless, it is intriguing that elevation of inflammatory cytokines in the CNS has been associated with suppressed synthesis of neurotrophic factors (especially BDNF) and compromised monoaminergic transmission (204), both of which have been reported in bipolar disorder

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Notably, AD patients exhibit heightened SOD activity, diminished glutamine synthetase activity, and elevated lipid peroxidation, collectively resulting in heightened oxidative stress and accumulation of free radicals