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Oxidative stress macrophage infiltration and CD163 expression are determinants of long-term renal outcome in macrohematuria-induced acute kidney injury of IgA nephropathy

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At the same time, ferroptosis is accompanied by excessive ROS production, resulting in depolarization of the mitochondrial membrane potential and opening of the mitochondrial permeability transition pore (MPTP), further leading to cell rupture (Ravingerov et al., 2020)