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Epidemiology, risk factors, and lifestyle modifications for gout

130 (4), 1007S1015S

4.2 mtDNA-induced inflammatory responses Akin to bacteria, mtDNA contains hypomethylated CpG motifs that are potent inducers of inflammation (Nakayama and Otsu, 2018)

J Immunol 189(6):26892695 Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daler-Plenker J, Guerci P, Huynh C, Knight JS (2020) Targeting potential drivers of COVID-19: neutrophil extracellular traps