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Dedicated Wholesale Accounts Approved business accounts receive access to a wholesale ordering environment designed specifically for larger-volume purchasing requirements, supporting organizations with recurring purchase needs under defined account terms

From a CPMG-based LO-NMR fragment screen, we identified one naphthalene sulfonic acid fragment hit ( 27 ) that binds to TRF1 TRFH with triple-digit micromolar affinity as measured by the R2KD assay

By engaging these two GPCR targets, it synergistically reduces food intake beyond what native amylin achieves