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Ilaris (canakinumab) - an IL-1 inhibitor used in treating periodic fever syndromes, Stills disease, and other rare auto-inflammatory disorders

doi: 10.2174/1570163817666200518074629 404 RochaOBe SilvaKSFde Carvalho JuniorMABMoraesDAlonsoAAlonsoLet al

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Such changes can increase gut permeability (leaky gut) and expose the mucosal immune system to bacterial products, thereby activating immune pathways that target distant tissues (Fig