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In summary, AS-IV negatively regulates fibroblast fibrosis, as primarily indicated by the remarkable promotion of the dephosphorylation of Smad2 and Smad3 in fibroblasts and restoration of Smad7 activity, indicating that AS-IV mediates positive feedback inhibition and the negative feedback enhancement of the TGF-1/Smads signaling pathway (77,78)

It plays a vital role in detoxification by neutralizing free radicals, supporting the immune system, and aiding in the regeneration of other antioxidants like vitamins C and E

Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

Chi square and Fisher exact tests were used to compare categorical variables, and t-test for continuous variables