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The NHS confirms that taking up to 2mg (2000 micrograms) daily is unlikely to cause harm, with no established upper limit in the UK

Recovery and tissue repair potential The regenerative effects of growth hormone make CJC-1295 interesting for recovery applications

Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA)

So the typical response of a B12 shot for someone who needs it is that they feel great, it wears off, and they are back to their previous baseline