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IRE1 and PERK are activated by autophosphorylation, while ATF6 is activated by intra-membrane cleavage, which releases its N-terminal fragment for transcription transactivation [94]

Both G6 and G7 exhibited the poorest metastatic nodules, especially for targeted nano-prodrug that the number of lung nodules was negligible with less than 5 lung metastases per mouse, suggesting a strong anti-metastasis effect of G7 (Fig

A growing but still modest body of clinical reports, mostly in musculoskeletal medicine and gastroenterology

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