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Safety analysis The incidence of adverse events in the two arms will be compared using the Pearson Chi-squared test or Fishers Exact test as required

Retatrutide monotherapy achieved 24.2% weight reduction in phase 2 trials, while cagrilintide combined with semaglutide (CagriSema) reached 22.7%

Estrogen treatment rescues ovariectomy-induced hepatic inflammation as well as systemic inflammation Loss of estrogen has been linked to activation of inflammatory pathways, specifically in postmenopausal women where this is prominent with increased emergence of liver disorders and cardiovascular diseases 66,67,68,69,70

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