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In 2015, the FDA addressed the concerns with a Safety Communication stating that it is safe and that the studies showing that it wasnt safe were all flawed.[ref] Lets take a look at some of the studies and then dig into the mechanism of action

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Hueber W, Sands BE, Lewitzky S, Vandemeulebroecke M, Reinisch W, Higgins PD, Wehkamp J, Feagan BG, Yao MD, Karczewski M, et al

231,232,233 However, it has been determined that while improving stability, PS modification can induce inflammatory responses and produce hepatotoxic effects