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Supasa et al

Ala141Pro Allelic disorder: Optic neuropathy 320 NSUN3 protein Location: Mitochondrial matrix Mitochondrial translation Epitranscriptome modification Methylation of mt-tRNA Met at wobble base C34 Required for deposition of m(5)C at the anticodon loop in mt-tRNA Met 5-formylcytosine generation from 5-methylcytosine (m(5)C) Clinical Onset age: 100 different mutations ~50% cause premature truncation Locations Spread through gene coding sequence Most in GTPase domain: Exons 8-16 3 end of coding region: Exons 27-28

A program that starts with a clean evaluation is the inverse of an unsupervised gym handoff, and it is the only version that keeps the patient in a documented care path

(3) Conjugating electrophilic compounds