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Side effects are: Red rash Increase skin acne Photosensitivity Bruising and bleeding at the injection site Vitamin D Vitamin D contributes to normal absorption/utilisation of calcium and phosphorus Contributes to normal blood calcium levels Contributes to the maintenance of normal bones Contributes to the maintenance of normal muscle function Contributes to the maintenance of normal teeth Contributes to the normal function of the immune system Has a role in the process of cell division Helps to reduce the risk of falling associated with postural instability and muscle weakness

Dyspnea is a normal manifestation of heavy physical or psychological exertion, but also may be caused by underlying conditions (both pulmonary and extrapulmonary)

Its prevalence increases significantly with age, rendering it the principal cause of blindness globally, responsible for approximately 48% of blindness cases [35]

We previously succeeded in identifying human ACF in situ using magnifying colonoscopy with methylene blue staining, and showed that the number of rectal ACF increased in a stepwise fashion from normal subjects to adenoma patients, and then to cancer patients, suggesting that ACF are precursor lesions to the adenomacarcinoma sequence in humans 13, 14