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Clinical trials reached phase II before the program was discontinued

Transglutaminase 2 crosslinks the glutathione S-transferase tag, impeding proteinprotein interactions of the fused protein

doi:10.1016/j.biomaterials.2021.121359 165

The destruction of membrane structure not only directly weakens sperm motility but also severely interferes with the ability of sperm to fuse with the oocyte plasma membrane during fertilization (spermoocyte fusion) (90)