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Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells

Inbal Houri 1 Claire Gage 2 Hooman Ebrahimi 2 Vathany Kulasingam 3 Guilherme Cancado 2 Kristel Leung 4 Bettina Hansen 1 Aliya Gulamhusein 4 Gideon Hirschfield 1 , 1 Toronto General Hospital, 2 Toronto Centre for Liver disease, 3 University Health Network, 4 University of Toronto Background: Certain auto-antibody profiles are considered highly specific for the diagnosis of autoimmune hepatitis (AIH)

doi:10.1111/nure.12001

When this imbalance is corrected through melatonin supplementation, some migraine patients experience an improvement in symptoms (Vogler 2006)