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When astrocytes take up glutamate, not only is there post-synaptic attenuation of nearby neurons, but within the astrocyte there is a switch from oxidative metabolism to aerobic glycolysis, and glucose is diverted from the TCA cycle to glycolysis and greater lactate production

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88,89 The main obstacles for the development of therapeutic cancer vaccines are: tumor evasion from recognition by the host immune system, tumor inhibition of immune responses, and defective induction of adaptive immunity

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