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202,203 Essentially, the imported disulphide-containing proteins undergo cathepsin-catalysed degradation in the lysosome, leading to the formation of cystine, which is then effluxed by the cystinosin transporter into the cytosol, where it is reduced to cysteine in a process that requires NADPH, leading to the formation of oxidised glutathione

Pinaud, F

16,17,18 To complement and extend this principle, additional immunization strategies have been developed to capture a broad spectrum of tumor antigens while addressing the limitations of neoantigen-personalized vaccines

Among these transporters, SLC13A3 knockdown significantly decreased the mRNA expression of SLC7A5 and SLC38A2 in both HepG2 and SNU398 cells (Supplementary Fig