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What treatment would be appropriate for this

As acetyl-CoA stores are depleted, the synthesis of NAGA an important cofactor of CPS I from acetyl-CoA and glutamate by NAGA synthetase is decreased

The potentiation of the L-Type Ca 2+ channel seen with 100 M TMAO (Figures 6, 7) would be expected to lead to an increase in cytoplasmic Ca 2+ accumulation during each contractile cycle