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Animal studies confirm: offspring of caffeine-exposed rats showed abnormal methylation patterns on genes controlling adrenal hormone production, with 51.2% born growth-restricted.[28] Most alarming: these epigenetic effects carried forward into grandchildren never exposed to caffeine themselves.[17] Your Genes Determine Your Risk The CYP1A2 gene has a well-studied polymorphism (rs762551)

For instance, H4 lysine 12 lactylation (H4K12la) induces smooth muscle cell senescence by promoting the expression of aging-related genes, thereby accelerating atherosclerosis [20]

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The estimated OR for an increase in BMI of 1 kg/m 2 was 1.25 (95% CI, 1.05, 1.57) for men and 1.05 (95% CI, 0.69, 1.59) for women