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C3a and C5a are critical immunomodulators that, in addition to serving as anaphylatoxins, also function as potent immunomodulatory agents through their cognate receptors (C3aR, C5aR1, and C5aR2 or C5L2), which are expressed on various innate and adaptive immune cells

KL1 also synergized with rifampicin even when infected macrophages were pretreated with antibiotics, suggesting that low-energy persisters may be resuscitated and sensitized (Fig