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A 1997 study in Journal of Physiology (Paris) reported effects of the pentadecapeptide in non-steroidal anti-inflammatory-agent gastrointestinal-lesion and adjuvant-arthritis models in rats, an early signal that the group intended to characterize the compound well beyond the gastrointestinal tract [3]

Leptin increases GH secretion in the short term, mainly via an increase in GHRH secretion and decrease in somatostatin expression

However, like any medical treatment, they can have side effects, such as pain at the injection site, mild diarrhea, or allergic reactions in rare cases