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Evodiamine has antitumor activity in many kinds of tumors, such as lung tumor, gastric tumor, colorectal tumor and ovarian tumor (201204)

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There are many documented clinical cases, all of them varied, with a multitude of symptoms, combinations of several of them, and uncertain onset, and with relatively good responses to treatment, but sometimes with very serious consequences if action is delayed: pancytopenia, organ failure, partial or permanent vision loss that is not recovered, heart attacks, and death

These effects are achieved by reducing immunosuppressive myeloid cells, increasing effector T cells, and enhancing the production of citrulline and NO