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Change history 15 May 2025 A Correction to this paper has been published: Abbreviations ICD-10: International Classification of Diseases AR: Androgen receptor ER: Estrogen receptor PR: Progesterone receptor GH: Growth hormone SARMs: Selective androgen receptor modulators DHT: Dihydrotestosterone ARE: Androgen-responsive elements ChIP: Chromatin immunoprecipitation ChIP-qPCR: ChIP-quantitative polymerase chain reaction Mef2: Myocyte enhancer factor 2 Mef2c: Myocyte enhancer factor 2 C ARKO: AR knockout MCK: Muscle creatine-kinase HSA: Human -skeletal actin MyoD: Myoblast determination protein 1 cARKO: Myofiber-specific ARKO Mylk4: Myosin light chain kinase 4 fmARKO: Fast-twitch muscle-specific ARKO ROS: Reactive oxygen species Fbp2: Fructose-bisphosphatase 2 Pcx: Pyruvate carboxylase Pfkfb3: 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 GSN: Gelsolin ADF: Actin-depolymerizing factor Hic-5: Hydrogen peroxide-inducible clone-5 ARA55: AR co-activator Hic-5 PXN: Paxillin GR: Glucocorticoid receptor SRC: Steroid receptor coactivator NCOA: Nuclear receptor coactivators PGC-1: Peroxisome proliferator-activated receptor gamma coactivator-1 PRC: PGC-1-related coactivator HDACs: Histone deacetylases NCoR: Nuclear Receptor Co-Repressor PKA: Protein kinase A PKC: Protein kinase C PLC: Phospholipase C Src: Sarcoma kinase PI3Ks: Phosphoinositide 3-kinases MAPKs: Mitogen-activated protein kinases IP 3 : Inositol trisphosphate PTX: Pertussis toxin MEK: Mitogen-activated extracellular signal-regulated kinase ERK: Extracellular signal-regulated kinase mTOR: Mammalian target of rapamycin FOXO3a: Forkhead box protein O3 mTORC1: mTOR Complex 1 FAK: Focal adhesion kinase IRSs: Insulin receptor substrates AMPK: AMP-activated protein kinase IGF-1: Insulin-like growth factor 1 IGF-1R: Insulin-like growth factor 1 receptor 4E-BP1: Eukaryotic translation initiation factor 4E-binding protein 1 eIF4E: Eukaryotic translation initiation factor 4E S6K1: Ribosomal protein S6 Kinase beta 1 MAFbx: Atrogin-1/muscle atrophy F-box MuRF1: Muscle RING finger 1 mAR: Membrane AR aGPCR: Adhesion G-protein coupled receptor GPR 133: G protein-coupled receptor 133 Fln: Filamin Rac 1: Ras-related C3 botulinum toxin substrate 1 Drp1: Dynamin-related protein 1 TGF-: Transforming growth factor- SMAD: Small mothers against decapentaplegic SMAD4: SMAD family member 4 Pax3: Paired Box 3 ADT: Androgen deprivation therapy IL-6: Interleukin-6 LPL: Lipoprotein lipase TNF: Tumor necrosis factor- IL-1: Interleukin-1 IL-10: Interleukin-10 CRP: C-reactive protein TRT: Testosterone replacement therapy References Frontera WR, Ochala J

During a retrospective study, researchers compared the effects of the ketogenic diet to modern anticonvulsant medications in 150 children

Compound 968 has an inhibitory effect on GLS2 and can inhibit the growth of BPTES-resistant breast cancer (Lukey et al., 2019), suggesting the different roles of GLS2 in different tumors

Chia, K