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Initially, a few in vitro evidence and small studies suggested that these medications might be helpful, however, large scale studies have found no such significance

Studies in patients with type 1 and type 2 diabetes have shown great improvement in glycemic control plus sustained reductions in food intake and meal size, as well as mild progressive weight loss, following acute and long-term adjunctive pramlintide treatment (120 g) (199)

Table 5 Tear biomarkers in patients with PD

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