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All procedures involving human subjects were reviewed and approved by the Human Subjects Committee at The Scripps Research Institute and conducted according to its requirements and National Institutes of Health guidelines

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Fully Integrated D-SNPs must meet the requirements of coordination-only D-SNPs and must also offer an aligned Medicaid plan that integrates the Medicare and Medicaid benefits

Abbreviations CQ: Chloroquine HCQ: Hydroxychloroquine COVID-19: novel Severe Acute Respiratory Syndrome Corona Virus 2 RA: Rheumatoid Arthritis SLE: Systemic Lupus Erythematosus CYP: cytochrome P450 S9: Metabolic activation system +: Positive effect : Weakly positive effect -: Negative (non mutagenic) effect MU: Mutagenicity assay CA: Chromosomal aberrations SCE: Sister-Chromatid Exchang SRL: Sex linked recessive lethals DD: DNA Damage DR: Inhibition of DNA Repair MN: Micronuclei formation CO: Carcinogenicity IL: Interleukin TLR: Toll-like receptor PBMC: Peripheral blood mononuclear cells TNF: Tumor necrosis factor NFAT: Nuclear Factor of Activated T-cells cGAS: Cyclic GMP-AMP synthase STING: Stimulator of interferon genes ACE2: Angiotensin-converting enzyme 2 GM-CSF: Granulocyte-colony stimulating factor References van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al