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To overcome this constraint, CNS-directed strategies often employ receptor-mediated transcytosis through engineered formats such as bispecific antibodies or brain-shuttle constructs targeting BBB receptors (e.g., TfR or insulin receptor) together with pathological targets such as A or tau, thereby improving brain delivery compared with conventional antibodies (Terstappen et al., 2021)

B12 Deficiency and Dermatological Symptoms Patients with a vitamin B12 deficiency may notice dermatological symptoms such as hyperpigmentation, vitiligo, or dry, irritated skin

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A severe Grade 3 tear will not heal in two weeks regardless of intervention